Regulation and Function of SUMO Modification

Regulation and function of SUMO modification.

Regulation of Protein Function by SUMO Modification

SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is likely to be important. Control of the levels of SUMOylation is brought about through a balance of conjugating and deconjugating activities, i.e...

Signalling pathways and the regulation of SUMO modification.

The modification of proteins by SUMO (small ubiquitin-related modifier) conjugation is becoming increasingly recognized as an important regulatory event. Protein SUMOylation can control a whole range of activities, including subcellular localization, protein-protein interactions and enzymatic activity. However, the SUMOylation process can itself be controlled. In the present review, the mechani...

Stat1 and SUMO modification.

Many proteins are known to undergo small ubiquitin-related modifier (SUMO) modification by an E1-, E2-, and E3-dependent ligation process. Recognition that protein inhibitor of activated signal transducers and activators of transcription (STATs) (PIAS) proteins are SUMO E3 ligases raised the possibility that STATs may also be regulated by SUMO modification. Consistent with this possibility, a S...

Regulation of HSF1 by stress-induced SUMO-1 modification

Heat shock transcription factor 1 (HSF1) mediates the induction of heat shock protein (hsp) gene expression in cells exposed to elevated temperature and other stress conditions. In response to stress HSF1 acquires DNA-binding ability and localizes to nuclear stress granules, but the molecular mechanisms which mediate these events are not understood. We report that HSF1 undergoes stress-induced ...